HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells.

@article{Bao2011HER2IW,
  title={HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells.},
  author={Wei Bao and Hai-jing Fu and Qiao-Sheng Xie and Lei Wang and Rui Zhang and Zhang-Yan Guo and Jing Zhao and Yan-ling Meng and Xin-ling Ren and Tao Wang and Qing Li and Bo-quan Jin and Li-bo Yao and Rui-an Wang and Dai-ming Fan and Si-Yi Chen and Lin-tao Jia and An-gang Yang},
  journal={Gastroenterology},
  year={2011},
  volume={141 6},
  pages={2076-2087.e6}
}
BACKGROUND & AIMS Human epidermal growth factor receptor 2 (HER2) (neu/ERBB2) is overexpressed on many types of cancer cells, including gastric cancer cells; HER2 overexpression has been associated with metastasis and poor prognosis. We investigated the mechanisms by which HER2 regulates cell migration and invasion. METHODS HER2 expression or activity was reduced in gastric cancer cell lines using small interfering RNAs or the monoclonal antibody, trastuzumab. We identified proteins that… CONTINUE READING