HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target.

@article{Grvalos2008HER2IG,
  title={HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target.},
  author={C Gr{\'a}valos and Antonio J. Jimeno},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2008},
  volume={19 9},
  pages={
          1523-9
        }
}
Gastric cancer is the second leading cause of cancer mortality in the world and its management, especially in advanced stages, has evolved relatively little. In particular, no targeted modality has so far been incorporated to its treatment armamentarium. HER2 overexpression is increasingly recognized as a frequent molecular abnormality, driven as in breast cancer by gene amplification. There is mounting evidence of the role of HER2 overexpression in patients with gastric cancer, and it has been… CONTINUE READING

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