HER2 in Gastric Cancer: An Immunohistochemical Study on Tissue Microarrays and the Coressponding Whole-Tissue Sections with a Supplemental Fish Study

@article{Galjevi2013HER2IG,
  title={HER2 in Gastric Cancer: An Immunohistochemical Study on Tissue Microarrays and the Coressponding Whole-Tissue Sections with a Supplemental Fish Study},
  author={Gorana Ga{\vs}ljevi{\'c} and Janez Lamovec and Juan Antonio Vidales Contreras and Vesna Zadnik and Mateja Blas and Slavko Ga{\vs}parov},
  journal={Pathology & Oncology Research},
  year={2013},
  volume={19},
  pages={855-865}
}
Since focal HER2 expression is an issue in GC, TMA construction from the paraffin-embedded surgically-obtained tissue may not reflect its real status. The aim of this study was to assess the HER2 status in tissue microarrays (TMAs) and the corresponding whole sections using HercepTest immunohistochemistry (IHC), and to correlate it and to assess the concordance of HER2 IHC and fluorescence in situ hybridization (FISH) in TMAs. Concordance of the HER2 expression status for 302 cases of gastric… CONTINUE READING
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