HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing

@inproceedings{Rueschoff2010HER2DI,
  title={HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing},
  author={Josef Rueschoff and Manfred Dietel and Gustavo Bruno Baretton and Susanne Arbogast and Axel Walch and Genevi{\'e}ve Monges and M P Chenard and Fr{\'e}d{\'e}rique Penault-Llorca and Iris E Nagelmeier and Werner Schlake and Heinz Hoefler and Hans Kreipe},
  booktitle={Virchows Archiv},
  year={2010}
}
Trastuzumab-based therapy has been shown to confer overall survival benefit in HER2-positive patients with advanced gastric cancer in a large multicentric trial (ToGA study). Subgroup analysis identified adenocarcinomas of the stomach and gastroesophageal (GE) junction with overexpression of HER2 according to immunohistochemistry (IHC) as potential responders. Due to recent approval of trastuzumab for HER2 positive metastatic gastric and GE-junction cancer in Europe (EMEA) HER2 diagnostics is… CONTINUE READING
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