HER2-dependent MMP-7 expression is mediated by activated STAT3.

  title={HER2-dependent MMP-7 expression is mediated by activated STAT3.},
  author={Guogang Yuan and Lu Qian and Ming Shi and Feng Lu and Dan Li and Meiru Hu and Ming Yu and Beifen Shen and Ning Guo},
  journal={Cellular signalling},
  volume={20 7},
MMP-7 expression is highly regulated at the level of transcription. An understanding of how the MMP-7 gene is regulated is critical to elucidate the mechanisms of MMP-7 overexpression in the early tumor development. In the present study, increased mRNA and protein expressions of MMP-7 were observed in MCF-7 cells stably overexpressing HER2 (MCF-7/HER2). The promoter activity of MMP-7 gene was upregulated in MCF-7/HER2 cells and significantly enhanced by HRG induction. Examination of the MMP-7… CONTINUE READING
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