HER2 Transmembrane Domain (TMD) Mutations (V659/G660) That Stabilize Homo- and Heterodimerization Are Rare Oncogenic Drivers in Lung Adenocarcinoma That Respond to Afatinib.

@article{Ou2017HER2TD,
  title={HER2 Transmembrane Domain (TMD) Mutations (V659/G660) That Stabilize Homo- and Heterodimerization Are Rare Oncogenic Drivers in Lung Adenocarcinoma That Respond to Afatinib.},
  author={S H Ignatius Ou and Alexa B Schrock and Eduard V Bocharov and Samuel J Klempner and Carolina Kawamura Haddad and Gary Steinecker and Melissa Lynne Johnson and Barbara Jennifer Gitlitz and Jon H. Chung and Paulo Vidal Campregher and Jeffrey S. Ross and Philip J. Stephens and Vincent A. Miller and James H Suh and Siraj M Ali and Vamsidhar Velcheti},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2017},
  volume={12 3},
  pages={446-457}
}
INTRODUCTION Erb-b2 receptor tyrosine kinase (HER2) transmembrane domain (TMD) mutations (HER2V659E, HER2G660D) have previously been identified in lung adenocarcinomas, but their frequency and clinical significance is unknown. METHODS We prospectively analyzed 8551 consecutive lung adenocarcinomas using hybrid capture-based comprehensive genomic profiling (CGP) at the request of the individual treating physicians for the purpose of making therapy decisions. RESULTS We identified 15 cases (0… CONTINUE READING

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