HER2/EGFR-AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer.

@article{Huang2018HER2EGFRAKTSS,
  title={HER2/EGFR-AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer.},
  author={Fei Huang and Qiaoni Shi and Yuzhen Li and Linlin Xu and Chi Xu and Fenfang Chen and Hai Wang and Hongwei Liao and Zai Kang Chang and Fang Liu and Xiang H. F. Zhang and Xin-Hua Feng and Jing-Dong J. Han and Shiwen Luo and Ye-Guang Chen},
  journal={Cancer research},
  year={2018},
  volume={78 21},
  pages={
          6073-6085
        }
}
TGFβ signaling inhibits cell proliferation to block cancer initiation, yet it also enhances metastasis to promote malignancy during breast cancer development. The mechanisms underlying these differential effects are still unclear. Here, we report that HER2/EGFR signaling switches TGFβ function in breast cancer cells from antiproliferation to cancer promotion. Inhibition of HER2/EGFR activity attenuated TGFβ-induced epithelial-mesenchymal transition and migration but enhanced the… CONTINUE READING
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