HER-2 gene amplification can be acquired as breast cancer progresses.

@article{Meng2004HER2GA,
  title={HER-2 gene amplification can be acquired as breast cancer progresses.},
  author={Songdong Meng and Debasish Tripathy and Sanjay Shete and Raheela Ashfaq and Barbara J. Haley and Steve Perkins and Peter D. Beitsch and Amanullah Khan and David H. Euhus and Cynthia R. C. Osborne and Eugene P. Frenkel and Susan J. Hoover and A. Marilyn Leitch and Edward J. Clifford and Ellen S. Vitetta and Larry Morrison and Dorothee M. Herlyn and Leon W M M Terstappen and Timothy P. Fleming and Tanja N. Fehm and Thomas F. Tucker and Nancy L Lane and Jianqiang Wang and Jonathan W. Uhr},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 25},
  pages={
          9393-8
        }
}
Amplification and overexpression of the HER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between primary tumor and metastases. Therefore, patients with HER-2-negative primary tumors rarely will receive anti-Her-2 antibody (trastuzumab, Herceptin) therapy. A very sensitive blood test was used to capture circulating tumor cells (CTCs) and evaluate their HER-2 gene status by fluorescence in situ hybridization. The HER-2 status of the primary tumor and… CONTINUE READING

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