HER-2-directed, small-molecule antagonists.

  title={HER-2-directed, small-molecule antagonists.},
  author={Michelle Arkin and Mark M. Moasser},
  journal={Current opinion in investigational drugs},
  volume={9 12},
Inactivation of the human epidermal growth factor receptor-2 (HER-2) tyrosine kinase holds significant promise as a cancer treatment hypothesis, making it a high-value target for drug discovery. Screening and structure-based efforts have led to the development of several classes of ATP analog inhibitors of the HER-2 tyrosine kinase. These efforts have been further enhanced by detailed structural information regarding its sibling kinase, the EGF receptor, and structural properties that can be… CONTINUE READING

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