HER-2-directed, small-molecule antagonists.

@article{Arkin2008HER2directedSA,
  title={HER-2-directed, small-molecule antagonists.},
  author={Michelle Arkin and Mark M. Moasser},
  journal={Current opinion in investigational drugs},
  year={2008},
  volume={9 12},
  pages={1264-76}
}
Inactivation of the human epidermal growth factor receptor-2 (HER-2) tyrosine kinase holds significant promise as a cancer treatment hypothesis, making it a high-value target for drug discovery. Screening and structure-based efforts have led to the development of several classes of ATP analog inhibitors of the HER-2 tyrosine kinase. These efforts have been further enhanced by detailed structural information regarding its sibling kinase, the EGF receptor, and structural properties that can be… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-3 of 3 extracted citations

Similar Papers

Loading similar papers…