HER-2 and TOP2A coamplification in urinary bladder cancer.

@article{Simon2003HER2AT,
  title={HER-2 and TOP2A coamplification in urinary bladder cancer.},
  author={Ronald Simon and Ramin Atefy and Urs Wagner and Thomas Forster and Andr{\'e} Fijan and James Bruderer and Kim A Wilber and Michael J{\"o}rg Mihatsch and Thomas Prof. Dr. Gasser and Guido Sauter},
  journal={International journal of cancer},
  year={2003},
  volume={107 5},
  pages={
          764-72
        }
}
HER-2/NEU is one of the most frequently amplified oncogenes and a potential therapeutic target in bladder cancer. In breast cancer, the adjacent TOP2A gene, the molecular target for several anticancer drugs, is frequently coamplified together with HER-2. To study the amplification and expression of TOP2A and HER-2 and associations with tumor phenotype and clinical outcome in bladder cancer, a tissue microarray containing 2,317 bladder tumor samples was analyzed by FISH and immunohistochemistry… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS, ESTIMATED 55% COVERAGE

63 Citations

0510'03'06'10'14'18
Citations per Year
Semantic Scholar estimates that this publication has 63 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…