HER-2 amplification is highly homogenous in gastric cancer.

  title={HER-2 amplification is highly homogenous in gastric cancer.},
  author={Andreas H Marx and Lars Tharun and Johanna Muth and Ana-Maria Dancau and Ronald Simon and Emre F. Yekebas and Jussuf Thomas Kaifi and Martina Mirlacher and Tim H. Br{\"u}mmendorf and C Carsten Bokemeyer and Jakob Robert Izbicki and Guido Sauter},
  journal={Human pathology},
  volume={40 6},
Her-2 is the molecular target for antibody-based treatment of breast cancer (trastuzumab). The potential benefit of anti-Her-2 therapy is currently investigated in several other HER-2-amplified cancers including gastric cancer. Although HER-2 amplification occurs in more than 10% of gastric cancers, potential heterogeneity of HER-2 amplification and overexpression could represent a major drawback for anti-Her-2 therapy. To address the potential applicability of trastuzumab in gastric cancer… CONTINUE READING


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