HER 2 / Neu ( ErbB 2 ) Signaling to Rac 1-Pak 1 Is Temporally and Spatially Modulated by Transforming Growth Factor B Shizhen

@inproceedings{Wang2006HER2,
  title={HER 2 / Neu ( ErbB 2 ) Signaling to Rac 1-Pak 1 Is Temporally and Spatially Modulated by Transforming Growth Factor B Shizhen},
  author={Emily Wang and Incheol Shin and Frederick Y. Wu and David Belais Friedman and Carlos L. Arteaga},
  year={2006}
}
In HER2 (ErbB2)-overexpressing cells, transforming growth factor B (TGF-B), via activation of phosphoinositide-3 kinase (PI3K), recruits actin and actinin to HER2, which then colocalizes with Vav2, activated Rac1, and Pak1 at cell protrusions. This results in prolonged Rac1 activation, enhanced motility and invasiveness, Bad phosphorylation, uncoupling of Bad/Bcl-2, and enhanced cell survival. The recruitment of the HER2/Vav2/Rac1/Pak1/actin/actinin complex to lamellipodia was abrogated by… CONTINUE READING

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