HER-2/neu protein: a target for antigen-specific immunotherapy of human cancer.

@article{Disis1997HER2neuPA,
  title={HER-2/neu protein: a target for antigen-specific immunotherapy of human cancer.},
  author={Mary Lenora Disis and Martin A. Cheever},
  journal={Advances in cancer research},
  year={1997},
  volume={71},
  pages={343-71}
}
The HER-2/neu oncogenic protein is a tumor antigen. Some patients with cancer have a preexistent immune response directed against the HER-2/neu protein. Effective cancer vaccines targeting HER-2/neu will be able to boost this immunity to potentially therapeutic levels. In addition, HER-2/neu-directed monoclonal antibody therapy has been effective in eradicating malignancy in animal models and has shown benefit in the treatment of human HER-2/neu-overexpressing cancers. This review outlines… CONTINUE READING

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