HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas.

@article{Press1997HER2neuGA,
  title={HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas.},
  author={Michael F Press and Leslie Bernstein and Pascal Alexandre Thomas and Lorraine Faxon Meisner and Jing Ye Zhou and Yanling Ma and Gene Hung and Richard A. Robinson and Cole Harris and A El-naggar and Dennis J. Slamon and Roger J. Phillips and Jeffrey S. Ross and Sandra R. Wolman and Kerry J Flom},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1997},
  volume={15 8},
  pages={2894-904}
}
PURPOSE The HER-2/neu gene codes for a membrane receptor protein that is homologous, but distinct from the epidermal growth factor receptor. This investigation was performed to validate fluorescence in situ hybridization (FISH) as a sensitive and specific method for assessing HER-2/neu gene amplification in archival tissue and to test whether this alteration is associated with poor prognosis. MATERIALS AND METHODS HER-2/neu gene amplification was determined by FISH in 140 archival breast… CONTINUE READING
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