HER-2/neu and hTERT cryptic epitopes as novel targets for broad spectrum tumor immunotherapy.

@article{Scardino2002HER2neuAH,
  title={HER-2/neu and hTERT cryptic epitopes as novel targets for broad spectrum tumor immunotherapy.},
  author={Antonio Scardino and David-Alexandre Gross and Pedro Miguel de Sousa Alves and Joachim L. Schultze and St{\'e}phanie Graff-Dubois and Olivier Faure and Sophie Tourdot and Salem Chouaib and Lee M. Nadler and François A. Lemonnier and Robert H. Vonderheide and Angelo Almeida Cardoso and Kostas Kosmatopoulos},
  journal={Journal of immunology},
  year={2002},
  volume={168 11},
  pages={5900-6}
}
Tolerance to tumor-nonmutated self proteins represents a major obstacle for successful cancer immunotherapy. Since this tolerance primarily concerns dominant epitopes, we hypothesized that targeting cryptic epitopes that have a low affinity for HLA could be an efficient strategy to breach the tolerance to tumor Ags. Using the P1Y heteroclitic peptide approach, we identified low affinity cryptic HLA-A*0201-restricted epitopes derived from two widely expressed tumor Ags, HER-2/neu and hTERT. The… CONTINUE READING