HER-2/neu amplification in benign breast disease and the risk of subsequent breast cancer.

@article{Stark2000HER2neuAI,
  title={HER-2/neu amplification in benign breast disease and the risk of subsequent breast cancer.},
  author={A H Stark and Barbara S. Hulka and S. J{\"o}ns and Debra B Novotny and Ann D. Thor and Lester E. Wold and Michael J. Schell and Lee Joseph Melton and Edison T. Liu and Kathleen Conway},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2000},
  volume={18 2},
  pages={267-74}
}
PURPOSE The purpose of this study was to determine whether the presence of HER-2/neu gene amplification and/or overexpression in benign breast disease was associated with an increased risk of subsequent breast cancer. PATIENTS AND METHODS We conducted a nested case-control study of a cohort of women who were diagnosed with benign breast disease at the Mayo Clinic and who were subsequently observed for the development of breast cancer. Patients who developed breast cancer formed the case group… CONTINUE READING

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