HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells.

@article{Moh2003HEPN1AN,
  title={HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells.},
  author={M. C. Moh and L. H. Lee and Xiaodong Yang and Shali Shen},
  journal={Journal of hepatology},
  year={2003},
  volume={39 4},
  pages={
          580-6
        }
}
BACKGROUND/AIMS Examining genes associated with human hepatocellular carcinoma (HCC) by subtractive hybridisation, we identified a novel transcript, designated as HEPN1, in non-tumorous liver. In this study, we aimed to evaluate HEPN1 gene expression in HCC patients, to characterise and to explore the functional significance of HEPN1 in vitro. METHODS One-step reverse transcription-polymerase chain reaction (RT-PCR) and real-time RT-PCR were employed to determine HEPN1 expression in 23 paired… Expand
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