HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Initiation of plasminogen activation on the surface of monocytes expressing the type II transmembrane serine protease matriptase


uPA (urokinase-type plasminogen activator) activates plasminogen with high efficiency when bound to its cellular receptor uPAR, but only after a prolonged lag phase during which generated plasmin activates pro-uPA. How the activity of this proteolytic system might be rapidly initiated is unknown. We have now found that 2 monocytic cell lines display… (More)


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