HEMATOLOGICAL AND MOLECULAR ANALYSIS OF β-THALASSEMIA AND Hb LEPORE IN CAMPANIA, ITALY

@article{Ferrara2001HEMATOLOGICALAM,
  title={HEMATOLOGICAL AND MOLECULAR ANALYSIS OF β-THALASSEMIA AND Hb LEPORE IN CAMPANIA, ITALY},
  author={M. Ferrara and S. M. Matarese and M. Francese and B. Borrelli and L. Coppola and A. Coppola and L. Esposito},
  journal={Hemoglobin},
  year={2001},
  volume={25},
  pages={29 - 34}
}
  • M. Ferrara, S. M. Matarese, +4 authors L. Esposito
  • Published 2001
  • Biology, Medicine
  • Hemoglobin
  • This epidemiological study was based on a hematological and a molecular analysis of 310 heterozygous β thalassemic and 75 carriers of Hb Lepore out of 3,000 microcythemic subjects from the Campania region of Italy. The molecular analysis of β chains and the δβ hybrid gene has shown different β chain defects, but only the Hb Lepore-Boston-Washington type in association with haplotypes I and V. The prevalence and distribution of these molecular defects in Campania show that they are linked to… CONTINUE READING
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