HELM: A Hierarchical Notation Language for Complex Biomolecule Structure Representation

  title={HELM: A Hierarchical Notation Language for Complex Biomolecule Structure Representation},
  author={Tianhong Zhang and Hongli Li and Hualin Xi and Robert V. Stanton and Sergio H. Rotstein},
  journal={Journal of chemical information and modeling},
  volume={52 10},
When biological macromolecules are used as therapeutic agents, it is often necessary to introduce non-natural chemical modifications to improve their pharmaceutical properties. The final products are complex structures where entities such as proteins, peptides, oligonucleotides, and small molecule drugs may be covalently linked to each other, or may include chemically modified biological moieties. An accurate in silico representation of these complex structures is essential, as it forms the… CONTINUE READING
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