HEAT repeats in the Huntington's disease protein

@article{Andrade1995HEATRI,
  title={HEAT repeats in the Huntington's disease protein},
  author={Miguel Andrade and Peer Bork},
  journal={Nature Genetics},
  year={1995},
  volume={11},
  pages={115-116}
}
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TLDR
J’ai identifie de nouveaux biomarqueurs cellulaires precoces associes a la mutation causale de la MH, which suggerent l’existence of mecanismes moleculaires encore inconnus et specifiques des phases les plus precoce de the maladie.
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TLDR
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Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus
TLDR
During chordate diversification, events of gain/loss, sliding, phase changes, and expansion of introns occurred in both vertebrate and ascidian lineages predominantly in the 5'-half of the htt gene, where there is also evidence of lineage-specific evolutionary dynamics in vertebrates.
Characterization of TOR complex 2 (TORC2) in "Saccharomyces cerevisiae"
TLDR
It is suggested that TORC2 exists in an oligomeric state and that AVO1 and likely AVO3 act as scaffold proteins required for the integrity ofTORC2, and thatAVO1 plays a role as an adaptor protein mediating efficient phosphorylation of substrates.
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