HEAT repeats in the Huntington's disease protein

@article{Andrade1995HEATRI,
  title={HEAT repeats in the Huntington's disease protein},
  author={Miguel A. Andrade and Peer Bork},
  journal={Nature Genetics},
  year={1995},
  volume={11},
  pages={115-116}
}
CRMP1 protein complexes modulate polyQ-mediated Htt aggregation and toxicity in neurons
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TLDR
J’ai identifie de nouveaux biomarqueurs cellulaires precoces associes a la mutation causale de la MH, which suggerent l’existence of mecanismes moleculaires encore inconnus et specifiques des phases les plus precoce de the maladie.
Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus
TLDR
During chordate diversification, events of gain/loss, sliding, phase changes, and expansion of introns occurred in both vertebrate and ascidian lineages predominantly in the 5'-half of the htt gene, where there is also evidence of lineage-specific evolutionary dynamics in vertebrates.
Characterization of TOR complex 2 (TORC2) in "Saccharomyces cerevisiae"
TLDR
It is suggested that TORC2 exists in an oligomeric state and that AVO1 and likely AVO3 act as scaffold proteins required for the integrity ofTORC2, and thatAVO1 plays a role as an adaptor protein mediating efficient phosphorylation of substrates.
Overview of Protein Structural and Functional Folds
This overview provides an illustrated, comprehensive survey of some commonly observed protein‐fold families and structural motifs, chosen for their functional significance. It opens with descriptions
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References

SHOWING 1-10 OF 24 REFERENCES
A structural basis of the interactions between leucine-rich repeats and protein ligands
TLDR
The unusual non-globular structure of ribonuclease inhibitor, its solvent-exposed parallel β-sheet and the conformational flexibility of the structure are used in the interaction; they appear to be the principal reasons for the effectiveness of leucine-rich repeats as protein-binding motifs.
Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form
TLDR
To study the HD gene product (huntingtin), monoclonal antibodies raised against four different regions of the protein are developed and detects the huntingtin in perikarya of some neurons, neuropiles, varicosities and as punctate staining likely to be nerve endings.
Genetics and molecular biology of Huntington's disease
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.
TLDR
A 9S protein complex from a Xenopus ovary cytosolic subfraction that constitutes this fraction's activity in recognizing a model nuclear import substrate and docking it at the nuclear pore complex is identified and characterized.
Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast
TLDR
Analysis of a temperature-conditional allele of VPS15 and of the defects in cellular PtdIns(3)P levels in various vps15 and vsp34 mutant strains has led to additional insights into the importance of Ptdins 3- kinase activity in intracellular localization, as well as the roles of Vps15p and Vps34p in vacuolar protein sorting.
Combining evolutionary information and neural networks to predict protein secondary structure
TLDR
This work extends the previous three‐level system of neural networks by using additional input information derived from multiple alignments using a position‐specific conservation weight as part of the input to increase performance and greatly increased accuracy.
Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases.
TLDR
Molecular modeling followed by optical, electron, and x-ray diffraction studies of a synthetic poly(L-glutamine) shows that it forms beta-sheets strongly held together by hydrogen bonds.
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