HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.

@article{Phillips2010HDMXLIE,
  title={HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.},
  author={Anna C Phillips and Amina Fas Teunisse and Suzanne Lam and Kirsten Lodder and Matthew Darley and Muhammad Emaduddin and Anja Wolf and Julia Richter and Job de Lange and Matty Verlaan-de Vries and Kristiaan J. Lenos and Anja B{\"o}hnke and Frank Bartel and Jeremy P Blaydes and Aart G. Jochemsen},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 38},
  pages={
          29111-27
        }
}
The p53 regulatory network is critically involved in preventing the initiation of cancer. In unstressed cells, p53 is maintained at low levels and is largely inactive, mainly through the action of its two essential negative regulators, HDM2 and HDMX. p53 abundance and activity are up-regulated in response to various stresses, including DNA damage and oncogene activation. Active p53 initiates transcriptional and transcription-independent programs that result in cell cycle arrest, cellular… CONTINUE READING

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