HDL3-related decreased serum paraoxonase (PON) activity in uremic patients: comparison with the PON1 allele polymorphism.

@article{Schiavon2002HDL3relatedDS,
  title={HDL3-related decreased serum paraoxonase (PON) activity in uremic patients: comparison with the PON1 allele polymorphism.},
  author={Renzo Schiavon and Paolo Battaglia and Emanuela De Fanti and Antonio Fasolin and Stefano Biasioli and Lino Targa and Giancesare Guidi},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2002},
  volume={324 1-2},
  pages={39-44}
}
BACKGROUND Patients with chronic renal failure on maintenance haemodialysis (HD) are at high risk of atherothrombotic events; an enhanced oxidant stress might have a major role. The decrease of human paraoxonase (PON1), an anti-oxidant high-density lipoprotein (HDL)-linked enzyme, is a possible mechanism for developing cardiovascular disease. To ascertain the causes of low PON1 in such patients, we investigated the contribution of both PON1 gene polymorphism and individual pattern of HDL… CONTINUE READING