HDL particles from type 1 diabetic patients are unable to reverse the inhibitory effect of oxidised LDL on endothelium-dependent vasorelaxation

@article{Persgol2007HDLPF,
  title={HDL particles from type 1 diabetic patients are unable to reverse the inhibitory effect of oxidised LDL on endothelium-dependent vasorelaxation},
  author={Laurence Pers{\'e}gol and Maud Foissac and Laurent Lagrost and Anne Athias and Philippe Gambert and Bruno Verg{\`e}s and Laurence Duvillard},
  journal={Diabetologia},
  year={2007},
  volume={50},
  pages={2384-2387}
}
In healthy individuals, HDL can counteract the inhibition of vasorelaxation induced by oxidised LDL. Several abnormalities such as increased size, glycation and decreased paraoxonase activity have been reported for HDL from type 1 diabetic patients. Thus, we hypothesised that the ability of HDL to protect vessels against impairments of vasorelaxation would be decreased in these patients. We compared the ability of HDL from 18 type 1 diabetic patients and 12 control participants to counteract… CONTINUE READING
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