HDL elevators and mimetics--emerging therapies for atherosclerosis.

  title={HDL elevators and mimetics--emerging therapies for atherosclerosis.},
  author={Manojit Pal and Sivaram Pillarisetti},
  journal={Cardiovascular & hematological agents in medicinal chemistry},
  volume={5 1},
High plasma levels of LDL cholesterol, triglycerides and low levels of HDL cholesterol are strong and independent risk factors of coronary heart disease (CHD). The first two abnormalities are addressed by a variety of drugs including statins, cholesterol absorption inhibitors, fibrates and niacin. Some of these drugs also elevate HDL albeit weakly. Thus treatments optimized for HDL elevation are still an unmet medical need. Low HDL-C is the most common lipoprotein abnormality in patients with… CONTINUE READING

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