HDL-cholesterol and cardiovascular disease: rethinking our approach.

  title={HDL-cholesterol and cardiovascular disease: rethinking our approach.},
  author={Hasan K Siddiqi and Daniel Kiss and Daniel R Rader},
  journal={Current opinion in cardiology},
  volume={30 5},
PURPOSE OF REVIEW A low level of plasma high density lipoprotein cholesterol (HDL-C) is a strong and independent risk factor for atherosclerotic cardiovascular disease (ASCVD). However, several large studies recently revealed that pharmacologic interventions that increase HDL-C concentration have not improved cardiovascular outcomes when added to standard therapy. In addition, specific genetic variants that raise HDL-C levels are not clearly associated with reduced risk of coronary heart… CONTINUE READING
Highly Cited
This paper has 529 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
11 Citations
54 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 11 extracted citations

529 Citations

Citations per Year
Semantic Scholar estimates that this publication has 529 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 54 references

Cholesterol , inflammation and innate immunity

  • DJ Rader, ET Alexander, GL Weibel
  • Nat Rev Immunol
  • 2015

Similar Papers

Loading similar papers…