HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property.

@article{OrtizMuoz2009HDLAA,
  title={HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property.},
  author={Guadalupe Ortiz-Mu{\~n}oz and Xavier Houard and Jos{\'e}-Luis Martin-Ventura and Brian Y. Ishida and St{\'e}phane Loyau and Patrick Rossignol and Juan-Antonio Moreno and John P. Kane and Robert J. Chalkley and Alma L. Burlingame and Jean-Baptiste Michel and Olivier Meilhac},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 9},
  pages={3129-39}
}
Various studies using proteomic approaches have shown that HDL can carry many proteins other than its constitutive apolipoprotein A-I (apoA-I). Using mass spectrometry and Western blotting, we showed the presence of alpha(1)-antitrypsin (AAT) (SERPINA1, serpin peptidase inhibitor, clade A, an elastase inhibitor) in HDL, isolated either by ultracentrifugation or by selected-affinity immunosorption using an anti-apoA-I column. Furthermore, we report that HDL possesses potent antielastase activity… CONTINUE READING
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