HDL and cardiovascular disease.

@article{Rader2014HDLAC,
  title={HDL and cardiovascular disease.},
  author={Daniel J. Rader and G. K. Hovingh},
  journal={Lancet},
  year={2014},
  volume={384 9943},
  pages={618-625}
}
The cholesterol contained within HDL is inversely associated with risk of coronary heart disease and is a key component of predicting cardiovascular risk. However, despite its properties consistent with atheroprotection, the causal relation between HDL and atherosclerosis is uncertain. Human genetics and failed clinical trials have created scepticism about the HDL hypothesis. Nevertheless, drugs that raise HDL-C concentrations, cholesteryl ester transfer protein inhibitors, are in late-stage… CONTINUE READING
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