HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms

  title={HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms},
  author={Mohamad Navab and Srinivasa T. Reddy and Brian J. Van Lenten and Alan M. Fogelman},
  journal={Nature Reviews Cardiology},
The lipoprotein HDL has two important roles: first, it promotes reverse cholesterol transport, and second, it modulates inflammation. Epidemiological studies show that HDL-cholesterol levels are inversely correlated with the risk of cardiovascular events. However, many patients who experience a clinical event have normal, or even high, levels of HDL cholesterol. Measuring HDL-cholesterol levels provides information about the size of the HDL pool, but does not predict HDL composition or function… CONTINUE READING
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