HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase‐dependent way

  title={HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase‐dependent way},
  author={Frederic F. Clermont and Nathalie Suarez Gonzalez and David Communi and Sebastian Franken and Jacques E. Dumont and Bernard Robaye},
  journal={Journal of Cellular Biochemistry},
We were looking by a proteomic approach for new phospho‐proteins involved during the early steps of the TNF + cycloheximide (CHX)‐induced apoptosis—preceding mitochondrial membrane permeabilization—of endothelial cells (BAEC). In the present study, we observed on the autoradiography from 2D gel of 32P‐labeled samples a string of proteins undergoing a complete dephosphorylation after 1 h of stimulation with TNF + CHX—while mitochondrial membrane permeabilization was observed after 3 h—identified… 
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