HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase‐dependent way

@article{Clermont2008HDGFID,
  title={HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase‐dependent way},
  author={Frederic F. Clermont and Nathalie Suarez Gonzalez and David Communi and Sebastian Franken and Jacques E. Dumont and Bernard Robaye},
  journal={Journal of Cellular Biochemistry},
  year={2008},
  volume={104}
}
We were looking by a proteomic approach for new phospho‐proteins involved during the early steps of the TNF + cycloheximide (CHX)‐induced apoptosis—preceding mitochondrial membrane permeabilization—of endothelial cells (BAEC). In the present study, we observed on the autoradiography from 2D gel of 32P‐labeled samples a string of proteins undergoing a complete dephosphorylation after 1 h of stimulation with TNF + CHX—while mitochondrial membrane permeabilization was observed after 3 h—identified… 
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References

SHOWING 1-10 OF 42 REFERENCES
Actin depolymerization and polymerization are required during apoptosis in endothelial cells
TLDR
It is suggested that the actin network of flattened cells is disrupted concomitantly to the morphological modifications associated to the apoptotic cell death, and that the cytochalasin‐sensitive reorganisation of actin is required to the formation of apoptotic blebs.
The mitochondrion in cell death control: certainties and incognita.
TLDR
It is elusive whether opening of the PTPC is the only physiological mechanism leading to mitochondrial membrane permeabilization, and the functional hierarchy among these proteins and their actual impact on the decision between death and life is elusive.
Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction*
TLDR
The results provide clear evidence for the involvement of a mitochondrial serine protease in the apoptotic pathway, emphasizing the critical role of the mitochondria in cell death.
HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*
TLDR
HtrA2 can, like DIABLO/Smac, prevent XIAP inhibition of active caspase 3in vitro and is able to counteract XIAP protection of mammalian NT2 cells against UV-induced cell death.
FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC)
TLDR
The data indicate that FLICE is the first in a cascade of ICE‐like proteases activated by CD95 and that this activation requires a functional CD95 DISC.
Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis*
TLDR
It is shown that caspase-3 is the primary executioner caspases in this system, necessary for cytochromec/dATP-inducible cleavage of fodrin, gelsolin, U1 small nuclear ribonucleoprotein, DNA fragmentation factor 45, and topoisomerase I, vimentin, Rb, and lamin B.
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