HDAC8 functions in spindle assembly during mouse oocyte meiosis

@inproceedings{Zhang2017HDAC8FI,
  title={HDAC8 functions in spindle assembly during mouse oocyte meiosis},
  author={Kemei Zhang and Yajuan Lu and Chaohua Jiang and Wei Liu and Jing Shu and Xueqin Chen and Yingjiao Shi and Ensheng Wang and Li Wang and Qinbo Hu and Yibo Dai and Bo Xiong},
  booktitle={Oncotarget},
  year={2017}
}
HDAC8 is a class I histone deacetylase that functions in a variety of biological processes through its non-histone substrates. However, its roles during oocyte meiosis remain elusive. Here, we document that HDAC8 localizes at spindle poles and positively participates in the regulation of microtubule organization and spindle assembly in mouse oocytes. Depletion of HDAC8 by siRNA-based gene silencing results in various spindle defects and chromosome misalignment during oocyte meiotic maturation… CONTINUE READING
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