HDAC6 is a microtubule-associated deacetylase

@article{Hubbert2002HDAC6IA,
  title={HDAC6 is a microtubule-associated deacetylase},
  author={Charlotte C. Hubbert and Amaris R. Guardiola and Rong‐guang Shao and Yoshiharu Kawaguchi and Akihiro Ito and Andrew Nixon and Minoru Yoshida and Xiao-fan Wang and Tso-pang Yao},
  journal={Nature},
  year={2002},
  volume={417},
  pages={455-458}
}
Reversible acetylation of α-tubulin has been implicated in regulating microtubule stability and function. The distribution of acetylated α-tubulin is tightly controlled and stereotypic. Acetylated α-tubulin is most abundant in stable microtubules but is absent from dynamic cellular structures such as neuronal growth cones and the leading edges of fibroblasts. However, the enzymes responsible for regulating tubulin acetylation and deacetylation are not known. Here we report that a member of the… Expand
Inhibition of HDAC6 Deacetylase Activity Increases Its Binding with Microtubules and Suppresses Microtubule Dynamic Instability in MCF-7 Cells*
TLDR
The evidence presented in this study indicated that the increased binding of HDAC6, rather than the acetylation per se, causes microtubule stability, in support of a hypothesis that in addition to its deacetylase function,HDAC6 might function as a MAP that regulates microtubules dynamics under certain conditions. Expand
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TLDR
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TLDR
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Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules
Human histone deacetylase 6 (HDAC6) is the major deacetylase responsible for removing the acetyl group from Lys40 of α-tubulin (αK40), which is located lumenally in polymerized microtubules. Here, weExpand
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TLDR
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TLDR
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TLDR
A surprising role for HDAC6 is uncovered in actin remodeling-dependent processes and the actin cytoskeleton is identified as an important target ofHDAC6-regulated protein deacetylation. Expand
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TLDR
The results suggest that Fry plays a crucial role in promoting the level of MT acetylation in the mitotic spindle by inhibiting the tubulin-deacetylase activity of SIRT2. Expand
HDAC6 deacetylates alpha tubulin in sperm and modulates sperm motility in Holtzman rat
TLDR
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TLDR
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