HDAC6 expression is correlated with better survival in breast cancer.

  title={HDAC6 expression is correlated with better survival in breast cancer.},
  author={Zhenhuan Zhang and Hiroko Yamashita and Tatsuya Toyama and Hiroshi Sugiura and Yoko Omoto and Y Ando and Keiko Mita and Maho Hamaguchi and Shin-ichi Hayashi and Hirotaka Iwase},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={10 20},
PURPOSE The structure and function of chromatin can be altered by modifications to histone. Histone acetylation in vivo is a dynamic reversible process governed by histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDAC6 is a unique isoform among the HDACs, and a gene expression pattern study, with cDNA microarray in MCF-7 cells, showed the HDAC6 gene to be late responsive, estrogen induced, and up-regulated. This led us to hypothesize that there was a link between levels of… CONTINUE READING
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