HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy.

@article{Lee2010HDAC6CA,
  title={HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy.},
  author={Jong-Soo Lee and Hiroshi Koga and Yoshiharu Kawaguchi and Waixing Tang and Esther C. T. Wong and Ya-sheng Gao and Udai Bhan Pandey and Susmita Kaushik and Emily Tresse and Jianrong Lu and J. Paul Taylor and Ana Mar{\'i}a Cuervo and Tso-pang Yao},
  journal={The EMBO journal},
  year={2010},
  volume={29 5},
  pages={969-80}
}
Autophagy is primarily considered a non-selective degradation process induced by starvation. Nutrient-independent basal autophagy, in contrast, imposes intracellular QC by selective disposal of aberrant protein aggregates and damaged organelles, a process critical for suppressing neurodegenerative diseases. The molecular mechanism that distinguishes these two fundamental autophagic responses, however, remains mysterious. Here, we identify the ubiquitin-binding deacetylase, histone deacetylase-6… CONTINUE READING
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