HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity.

@article{Sun2009HDAC4RV,
  title={HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity.},
  author={Xiaojuan Sun and Lei Wei and Qian Chen and Richard M. Terek},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 33},
  pages={21881-90}
}
Chondrosarcoma is a primary bone tumor with a dismal prognosis; most patients with this disease develop fatal pulmonary metastases, suggesting the need for a better systemic treatment. Anti-angiogenesis treatment may be useful, because angiogenesis is critical for both tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is the most potent pro-angiogenic factor and is regulated by pathways related to the normal physiologic response to hypoxia and genetic alterations related to… CONTINUE READING
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