HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling.

@article{Godman2008HDAC3IM,
  title={HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling.},
  author={Cassandra A. Godman and Rashmi Raj Joshi and Brendan Tierney and Emily Greenspan and Theodore P. Rasmussen and Hsin-wei Wang and Dong-Guk Shin and Daniel W Rosenberg and Charles Giardina},
  journal={Cancer biology & therapy},
  year={2008},
  volume={7 10},
  pages={1570-80}
}
Histone deacetylase 3 (HDAC3) is overexpressed in approximately half of all colon adenocarcinomas. We took an RNAi approach to determine how HDAC3 influenced chromatin modifications and the expression of growth regulatory genes in colon cancer cells. A survey of histone modifications revealed that HDAC3 knockdown in SW480 cells significantly increased histone H4-K12 acetylation, a modification present during chromatin assembly that has been implicated in imprinting. This modification was found… CONTINUE READING