HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

  title={HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage},
  author={Jin Young Kim and Siming Shen and Karen C. Dietz and Ye He and Owain W. Howell and R Reynolds and Patrizia Casaccia},
  booktitle={Nature Neuroscience},
Histone deacetylase 1 (HDAC1) is a nuclear enzyme involved in transcriptional repression. We detected cytosolic HDAC1 in damaged axons in brains of humans with multiple sclerosis and of mice with cuprizone-induced demyelination, in ex vivo models of demyelination and in cultured neurons exposed to glutamate and tumor necrosis factor-α. Nuclear export of HDAC1 was mediated by the interaction with the nuclear receptor CRM-1 and led to impaired mitochondrial transport. The formation of complexes… CONTINUE READING


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