HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation.

Abstract

Metabolic bioactivation of polycyclic aromatic hydrocarbons, such as the environmental procarcinogen benzo[a]pyrene, is catalyzed by a cytochrome P450 monooxygenase encoded by the substrate-inducible Cyp1a1 gene. Cyp1a1 induction requires trans-activation by the heterodimeric transcriptional complex formed by the liganded Ah receptor (AHR) and its partner… (More)

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@article{Schnekenburger2007HDAC1BT, title={HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation.}, author={Michael Schnekenburger and Li Peng and Alvaro Puga}, journal={Biochimica et biophysica acta}, year={2007}, volume={1769 9-10}, pages={569-78} }