HDAC modulation and cell death in the clinic.

@article{Dellaversana2012HDACMA,
  title={HDAC modulation and cell death in the clinic.},
  author={Carmela Dell'aversana and Ilaria Lepore and Lucia Altucci},
  journal={Experimental cell research},
  year={2012},
  volume={318 11},
  pages={
          1229-44
        }
}
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are two opposing classes of enzymes, which finely regulate the balance of histone acetylation affecting chromatin packaging and gene expression. Imbalanced acetylation has been associated with carcinogenesis and cancer progression. In contrast to genetic mutations, epigenetic changes are potentially reversible. This implies that epigenetic alterations are amenable to pharmacological interventions. Accordingly, some epigenetic… CONTINUE READING

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