HDAC inhibitors induce cell cycle arrest, activate the apoptotic extrinsic pathway and synergize with a novel PIM inhibitor in Hodgkin lymphoma-derived cell lines.

@article{MartnSnchez2011HDACII,
  title={HDAC inhibitors induce cell cycle arrest, activate the apoptotic extrinsic pathway and synergize with a novel PIM inhibitor in Hodgkin lymphoma-derived cell lines.},
  author={Esperanza Mart{\'i}n-S{\'a}nchez and Margarita S{\'a}nchez-Beato and M. Elena Rodr{\'i}guez and Beatriz S{\'a}nchez-Espiridi{\'o}n and Cristina G{\'o}mez-Abad and James R. Bischoff and Miguel {\'A}ngel Piris and Africa Garc{\'i}a-Orad and Juan Fernando V{\'e}lez Garc{\'i}a},
  journal={British journal of haematology},
  year={2011},
  volume={152 3},
  pages={352-6}
}
Molecular studies have shown that the tumoural component of classical Hodgkin lymphoma (cHL), Hodgkin and ReedSternberg (HRS) cells, shows a profound disturbance of the cell-cycle and apoptosis regulation (Küppers, 2009). Although cHL is often curable, there remains a group of patients who do not achieve remission with initial therapy and about 30% patients will die of the disease. Therefore, novel targeted agents need to be developed to reduce treatment-related toxicity and to further patient… CONTINUE READING
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