HDAC inhibitors in kidney development and disease

  title={HDAC inhibitors in kidney development and disease},
  author={Lauren L. Brilli and Lisa M. Swanhart and Mark P. de Caestecker and Neil A Hukriede},
  booktitle={Pediatric Nephrology},
The discovery that histone deacetylase inhibitors (HDACis) can attenuate acute kidney injury (AKI)-mediated damage and reduce fibrosis in kidney disease models has opened the possibility of utilizing HDACis as therapeutics for renal injury. Studies to date have made it abundantly clear that HDACi treatment results in a plethora of molecular changes, which are not always linked to histone acetylation, and that there is an essential need to understand the specific target(s) of any HDACi of… CONTINUE READING
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