HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: implication for chemosensitization.

@article{Kim2011HDACID,
  title={HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: implication for chemosensitization.},
  author={Hanna Kim and Su-Nam Kim and Yeon-suk Park and Nam Hyun Kim and Jeung-Whan Han and Hoi Young Lee and Yong Kee Kim},
  journal={International journal of oncology},
  year={2011},
  volume={38 3},
  pages={807-12}
}
Although histone deacetylase (HDAC) inhibitors are emerging as a promising class of cancer chemotherapeutic agents, their effects on multidrug resistance (MDR) are poorly understood. In this study, we investigated whether HDAC inhibitors overcome MDR phenotype. HDAC inhibitors suppress the growth of both MDR positive cancer cells KBV20C and its parental cells KB with similar potencies. In parallel, histone acetylation and p21WAF1 expression by the HDAC inhibitors were similarly increased in… CONTINUE READING

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