HDAC inhibitors: roles of DNA damage and repair.

@article{Robert2012HDACIR,
  title={HDAC inhibitors: roles of DNA damage and repair.},
  author={Carine Robert and Feyruz V Rassool},
  journal={Advances in cancer research},
  year={2012},
  volume={116},
  pages={87-129}
}
Histone deacetylase inhibitors (HDACis) increase gene expression through induction of histone acetylation. However, it remains unclear whether specific gene expression changes determine the apoptotic response following HDACis administration. Herein, we discuss evidence that HDACis trigger in cancer and leukemia cells not only widespread histone acetylation but also actual increases in reactive oxygen species (ROS) and DNA damage that are further increased following treatment with DNA-damaging… CONTINUE READING
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