HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy.

@article{Khan2007HDACIA,
  title={HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy.},
  author={Zahidul Islam Khan and Monira Akhtar and Thomas Asklund and Bengt Juliusson and Per Almqvist and Tomas J. Ekstr{\"o}m},
  journal={Experimental cell research},
  year={2007},
  volume={313 13},
  pages={
          2958-67
        }
}
Enzyme prodrug therapy using neural progenitor cells (NPCs) as delivery vehicles has been applied in animal models of gliomas and relies on gap junction communication (GJC) between delivery and target cells. This study investigated the effects of histone deacetylase (HDAC) inhibitors on GJC for the purpose of facilitating transfer of therapeutic molecules from recombinant NPCs. We studied a novel immortalized midbrain cell line, NGC-407 of embryonic human origin having neural precursor… CONTINUE READING
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