HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response

@inproceedings{Chusri2016HCVIT,
  title={HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response},
  author={Pattranuch Chusri and Kattareeya Kumthip and Jian Hong and Chuanlong Zhu and Xiaoqiong Duan and Nikolaus Jilg and Dahlene Fusco and Cynthia Brisac and Esperance A K Schaefer and Dachuan Cai and Lee F. Peng and Niwat Maneekarn and Wenyu Lin and Raymond Tsang Chi Chung},
  booktitle={Scientific reports},
  year={2016}
}
HCV replication disrupts normal endoplasmic reticulum (ER) function and activates a signaling network called the unfolded protein response (UPR). UPR is directed by three ER transmembrane proteins including ATF6, IRE1, and PERK. HCV increases TGF-β1 and oxidative stress, which play important roles in liver fibrogenesis. HCV has been shown to induce TGF-β1… CONTINUE READING