HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells.

@article{Florentin2012HCVGE,
  title={HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells.},
  author={Jonathan Florentin and Besma Aouar and Cl{\'e}lia Dental and Christine Thumann and Guyl{\`e}ne Firaguay and Françoise Gondois-Rey and Vassili Soumelis and Thomas F Baumert and Jacques A Nun{\`e}s and Daniel Olive and Ivan Hirsch and Rů{\vz}ena Str{\'a}nsk{\'a}},
  journal={Blood},
  year={2012},
  volume={120 23},
  pages={4544-51}
}
The elimination of hepatitis C virus (HCV) in > 50% of chronically infected patients by treatment with IFN-α suggests that plasmacytoid dendritic cells (pDCs), major producers of IFN-α, play an important role in the control of HCV infection. However, despite large amounts of Toll-like receptor 7-mediated IFN-α, produced by pDCs exposed to HCV-infected hepatocytes, HCV still replicates in infected liver. Here we show that HCV envelope glycoprotein E2 is a novel ligand of pDC C-type lectin… CONTINUE READING
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