HCV NS3 sequencing as a reliable and clinically useful tool for the assessment of genotype and resistance mutations for clinical samples with different HCV-RNA levels.

@article{Maio2016HCVNS,
  title={HCV NS3 sequencing as a reliable and clinically useful tool for the assessment of genotype and resistance mutations for clinical samples with different HCV-RNA levels.},
  author={Velia Chiara Di Maio and Valeria Cento and Daniele di Paolo and Marianna Aragri and Francesco De Leonardis and Monica Tontodonati and Valeria Micheli and Maria Concetta Bellocchi and Fabio Antonucci and Aldo Bertoli and Ilaria Lenci and Martina Milana and Laura Gianserra and Mahmoud Melis and Antonio Di Biagio and Cesare Sarrecchia and Loredana Sarmati and Simona Landonio and Simona Francioso and Lara Lambiase and Laura Ambra Nicolini and Simona Marenco and Lorenzo Nosotti and Valerio Giannelli and Massimo Siciliano and Dante Romagnoli and Adriano Maria Pellicelli and Jacopo Vecchiet and Carlo F Magni and Sergio Babudieri and Mar{\'i}a Stella Mura and Gloria Taliani and Cm Mastroianni and Umberto Vespasiani-Gentilucci and Mario Romano and Filomena Morisco and A Gasbarrini and Vincenzo Vullo and S. Bruno and Chiara Baiguera and Caterina Pasquazzi and Giuseppe Tisone and Antonino Picciotto and Massimo Andreoni and Giustino Parruti and Giuliano Rizzardini and Mario Angelico and Carlo Federico Perno and Francesca Ceccherini-Silberstein},
  journal={The Journal of antimicrobial chemotherapy},
  year={2016},
  volume={71 3},
  pages={
          739-50
        }
}
OBJECTIVES This study aims to evaluate the reliability and clinical utility of NS3 sequencing in hepatitis C virus (HCV) 1-infected patients who were candidates to start a PI-containing regimen. METHODS NS3 protease sequencing was performed by in-house-developed HCV-1 subtype-specific protocols. Phylogenetic analysis was used to test sequencing reliability and concordance with previous genotype/subtype assignment by commercial genotyping assays. RESULTS Five hundred and sixty-seven HCV… CONTINUE READING

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