HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells

@inproceedings{Chen2014HCVGR,
  title={HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells},
  author={Wei Chen and Yongfen Xu and Hua Li and Wanyin Tao and Yu Xiang and Bing Huang and Junqi Niu and Jin Zhong and Guangxun Meng},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Elevated plasma levels of IL-1β and IL-18 from patients with hepatitis C virus (HCV) infection indicate a possible activation of inflammasome by HCV. METHODOLOGY/PRINCIPAL FINDINGS To demonstrate whether HCV infection activates the inflammasome, we investigated inflammasome activation from HCV infected hepatic Huh7 cells, or monocytic cells and THP-1 derived macrophages challenged with HCV virions, but no any inflammasome activation was detected in these cells. However, when we… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 67 references

Similar Papers

Loading similar papers…