HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.

@article{Huang1999HCPTPAAP,
  title={HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.},
  author={Li Huang and Sabita Sankar and Chunru Lin and Christopher D. Kontos and Alfred D Schroff and Eugene H. Cha and Simon Feng and Shengwen Li and Zhenbao Yu and Robert L Van Etten and Michael A. Blanar and Kevin G. Peters},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 53},
  pages={38183-8}
}
Angiogenesis is a tightly controlled process in which signaling by the receptors for vascular endothelial growth factor (VEGF) plays a key role. In order to define signaling pathways downstream of VEGF receptors (VEGFR), the kinase domain of VEGFR2 (Flk-1) was used as a bait to screen a human fetal heart library in the yeast two-hybrid system. One of the signaling molecules identified in this effort was HCPTPA, a low molecular weight, cytoplasmic protein tyrosine phosphatase. Although HCPTPA… CONTINUE READING
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