HCO(3)(-) secretion in the rat colonic crypt is closely linked to Cl(-) secretion.

  title={HCO(3)(-) secretion in the rat colonic crypt is closely linked to Cl(-) secretion.},
  author={John P. Geibel and Satish Kumar Singh and Vazhaikkurichi M. Rajendran and Henry Joseph Binder},
  volume={118 1},
BACKGROUND & AIMS The mechanism of colonic HCO(3)(-) secretion has not been established largely because of a lack of experimental methods for its detailed study. The present studies were designed to establish whether the isolated, perfused crypt of the rat distal colon is an excellent model to study HCO(3)(-) movement and the mechanism of colonic HCO(3)(-) secretion. METHODS HCO(3)(-) secretion was determined in isolated, microperfused crypts by measuring [HCO(3)(-)] by microcalorimetry on… CONTINUE READING
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